Epithalon is a synthetic peptide studied for its potential to regulate aging processes and promote cellular longevity. Discovered in the 1980s, it is known to support melatonin production, improving sleep cycles and immune function, which decline with age. Research also suggests it may protect against oxidative stress and DNA damage, contributing to overall health and wellness.
Epithalon is a synthetic peptide composed of four amino acids with the sequence alanine-glutamate-asparagine-glycine. It is derived from epithalamin, a naturally occurring polypeptide produced in the pineal gland.
Lithuania Research indicates that Epithalon may play a role in regulating cellular processes, particularly those associated with ageing. Its primary mechanism involves the activation of telomerase. It is an enzyme that promotes the repair and elongation of telomeres. These are the protective caps at the ends of chromosomes. Shortened telomeres are linked to cell senescence and age-related decline. Due to its potential impact on cellular longevity, Epithalon is being studied for its applications in gerontology and age management therapies.
Epithalon works by influencing several cellular mechanisms linked to ageing and telomere maintenance. Its primary action is the activation of telomerase, an enzyme critical for maintaining telomere length. Telomerase repairs and extends telomeres, which naturally shorten during cell division. By preserving telomere integrity, Epithalon helps delay cellular senescence and promotes healthier cell replication.
Furthermore, Epithalon impacts the regulation of gene expression. It can modulate the activity of certain genes involved in cell cycle control and DNA repair. Studies suggest that it enhances the stability of the genome by reducing oxidative damage to DNA.
Epithalon also improves the function of the pineal gland. This is significant, as the pineal gland affects circadian rhythms and hormonal regulation. By enhancing melatonin production, Epithalon may indirectly support cellular repair and immune system activity.
Research has also shown that Epithalon has antioxidant properties. It helps reduce oxidative stress by neutralising free radicals, which contribute to cellular damage and ageing. This combined action on telomeres, genetic regulation, and oxidative damage positions Epithalon as a promising compound for age-related studies.
Molecular Formula: C14H22N4O9
Molecular Weight: 390.349
Sequence: H-Ala-Glu-Asp-Gly-OH
View our Epithalon High-Performance Liquid Chromatography (HPLC) Certificate here.
Buy Epithalon Nasal Spray
Epithalon nasal spray is an alternative delivery method being explored in research. It allows absorption through the nasal mucosa, potentially avoiding injections. While more convenient and non-invasive, its safety and effectiveness are still under investigation and not established. Like other forms of Epithalon, it is not approved for Lithuania medical use and is limited to research.
Buy Epithalon nasal spray Lithuania for clinical research from Direct Sarms, available in 15ml and 30ml bottles here.
Buy Epithalon Peptide Vial
Buy Epithalon peptide vial, a synthetic tetrapeptide in lyophilised powder form for research purposes. Reconstitute with a sterile solution like bacteriostatic water for use in research. The vial ensures precise dosing and long-term stability. Note: Epithalon is not approved for medical use and is limited to research settings.
Buy Epithalon Peptide Vial Lithuania for research from Direct Sarms. Available here in a 10mg vial and a vial kit with bacteriostatic water and syringes.
How does Epithalon work?
Epithalon is believed to function by increasing the activity of telomerase, an enzyme that helps maintain and elongate telomeres. It also supports melatonin production and exhibits antioxidant properties, contributing to its potential anti-ageing benefits.
Is Epithalon safe for use?
Current Lithuania research indicates that Epithalon is generally well-tolerated in studies. However, further clinical trials are required to definitively establish its safety profile and long-term effects.
What are the possible benefits of Epithalon?
Epithalon may offer benefits like improved telomere maintenance, stronger antioxidant defense, better circadian rhythm regulation, and support for cellular and immune health.
Can Epithalon truly reverse ageing?
Lithuania Research suggests Epithalon may slow cellular aging and support healthier aging, but it does not reverse aging. Its role is to delay age-related cellular changes.
How is Epithalon administered?
In research settings, Epithalon is typically administered via injections, although other delivery methods are being explored. It is important to note that it is not yet approved for general medical use.
Is Epithalon legal?
The legal status of Epithalon varies by country and its peptide regulations. In the United States, the FDA has not approved Epithalon for medical use. It is classified as a research chemical and is only available for scientific research. It cannot be sold as a supplement or medication. Those interested in Epithalon should check local Lithuania laws and consult qualified professionals.
For more information, explore our latest blog posts dedicated to Epithalon peptides.
Buy Epithalon peptides Lithuania from Direct Sarms, a trusted supplier for research-grade peptides. Available in lyophilised powder vials, Epithalon is designed for laboratory use and offers exceptional purity and quality, ensuring reliable and reproducible research outcomes.
These peptides are shipped under strict quality control to maintain integrity and efficacy. By choosing Direct Sarms Lithuania for your Epithalon needs, you ensure accurate dosing and dependable results for your scientific studies.
[1] Vladimir N Anisimov, Vladimir Kh Khavinson, Irina G Popovich, Mark A Zabezhinski, et al (2003) Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice – Biogerontology, 2003, Volume 4 (Issue 4), Pages 193-202.
[2] V N Anisimov, S V Mylnikov, and V K Khavinson (1998) Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats – Mechanisms of Ageing and Development, 1998 Jun 15, Volume 103 (Issue 2), Pages 123-32.
[3] Sigal Gery 1, Naoki Komatsu, Lilit Baldjyan, Andrew Yu, et al (2006) The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells – Molecular Cell, 2006 May 5, Volume 22 (Issue 3), Pages 375-82.
[4] O V Korkushko, B A Lapin, N D Goncharova, V Kh Khavinson, et al (2007) Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people – Adv Gerontol, 2007, Volume 20 (Issue 1), Pages 74-85.
[5] Vladimir N. Anisimov, Vladimir Kh. Khavinson, I.G. Popovich, and Mark A. Zabezhinski (2002) Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats – Cancer Letters, Volume 183, Issue 1, 8 September 2002, Pages 1-8.
[6] Vladimir Khavinson, Michael Razumovsky, Svetlana Trofimova, Roman Grigorian, and Anna Razumovskaya (2002) Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa – Neuro Endocrinology Letters, 2002 Aug, Volume 23 (Issue 4), Pages 365-8.
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